2025
A Hedgehog-Induced Homeodomain Cascade Couples Progenitor Identity to Neuronal Diversification
Brandão SC, Ramirez L, Züfle P, Walter AM, Silies M, Martelli C (2025)
Undoing of firing rate adaptation enables invariant population codes
Henning M, Ketkar M, Lüffe T, Gohl D, Clandinin TR, Silies M (2025)
Inhibitory columnar feedback neurons are required for motion processing in Drosophila
reviewed preprint in eLife (coming out soon)
bioRxiv https://doi.org/10.1101/2025.07.28.667319
2024
Gür B, Ramirez L, Cornean J, Thurn F, Molina-Obando S, Ramos-Traslosheros G, Silies M (2024)
Neural pathways and computations that achieve stable contrast processing tuned to natural scenes
Nature Communications 15, 8580. https://doi.org/10.1038/s41467-024-52724-5
Cornean J, Molina-Obando S, Gür B, Bast A, Ramos-Traslosheros G, Chojetzki J, Lörsch L, Ioannidou M, Taneja R, Schnaitmann C, Silies M (2024)
Heterogeneity of synaptic connectivity in the fly visual system
Nature Communications 15, 1570. https://doi.org/10.1038/s41467-024-45971-z
2023
Ketkar M, Shao S, Gjorgjieva J, Silies M (2023)
Multifaceted luminance gain control beyond photoreceptors in Drosophila
Current Biology 33:2632-2645, doi.org/10.1016/j.cub.2023.05.024
Bueno D, Dey PN, Schacht T, Wolf C, [...] , Peper J, Silies M, Frauenknecht KBM, Schäfer MKE, Methner A (2023)
NECAB2 is an endosomal protein important for striatal function
Free Radical Biology and Medicine 208, 643-656. doi.org/10.1016/j.freeradbiomed.2023.09.003
Thurn F, Silies M (2023)
Mechanismen und Herausforderungen des Bewegungssehens
BIOspektrum 29: 123-126. https://link.springer.com/article/10.1007/s12268-023-1916-9
2022
Ketkar M, Gür B, Molina-Obando S, Ioannidou M, Martelli C, Silies M (2022)
First-order visual interneurons distribute distinct contrast and luminance information across ON and OFF pathways to achieve stable behavior
eLife 11:e74937. doi: 10.7554/eLife.74937
Henning M, Ramos-Traslosheros G, Gür B, Silies M (2022)
Populations of local direction-selective cells encode global motion patterns generated by self-motion
Science Advances 8:3. doi: 10.1126/sciadv.abi7112
2021
Ramos-Traslosheros G and Silies M (2021)
The physiological basis for contrast opponency in motion computation in Drosophila
Nature Communications 12: 4987. doi: 10.1038/s41467-021-24986-w
Akhtar J, Renaud Y, Albrecht S, Ghavi-Helm Y, Roignant J-Y, Silies M, Junion G. (2021)
m 6 A RNA methylation regulates promoter- proximal pausing of RNA polymerase II
Molecular Cell, 81:3356-3367. doi: 10.1016/j.molcel.2021.06.023
Brandão S C, Silies M, Martelli C (2021)
Adaptive temporal processing of odor stimuli
Cell Tissue Research, 383:125-141. doi: 10.1007/s00441-020-03400-9
2020
Ketkar MD, Sporar K, Gür B, Ramos-Traslosheros G, Seifert M, Silies M (2020)
Luminance Information Is Required for the Accurate Estimation of Contrast in Rapidly Changing Visual Contexts.
Current Biology, 30: 657-669, doi: 10.1016/j.cub.2019.12.038
Neuert H, Deing P, Krukkert K, Naffin E, Steffes G, Risse B, Silies M, Klämbt C (2020)
The Drosophila NCAM homologue Fas2 signals independent of adhesion.
Development, 147(2): pii: dev.181479. doi: 10.1242/dev.181479.
Gür B, Sporar K, Lopez-Behling A, Silies M (2020)
Distinct expression of potassium channels regulates visual response properties of lamina neurons in Drosophila melanogaster.
J Comp Phys A, 206: 273-287, doi: 10.1007/s00359-019-01385-7
2019
Molina-Obando S, Vargas-Fique JF, Henning M, Gür B, Schladt TM, Akhtar J, Berger TK, Silies M (2019) ON selectivity in Drosophila vision is a multisynaptic process involving both glutamatergic and GABAergic inhibition.
eLife, pii: e49373. doi: 10.7554/eLife.49373.
Akhtar J, More P, Albrecht S, Marini F, Kaiser W, Kulkarni A, Wojnowski L, Fontaine JF, Andrade-Navarro MA, Silies M, Berger C (2019)
TAF-ChIP: an ultra-low input approach for genome-wide chromatin immunoprecipitation assay.
Life Sci Alliance: e201900318. doi: 10.26508/lsa.201900318
2018
Liou NF, Lin SH, Chen YJ, Tsai KT, Yang CJ, Lin TY, Wu TH, Lin HJ, Chen YT, Gohl DM, Silies M, Chou YH (2018)
Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit
Nat Communication 9: 2232. doi: 10.1038/s41467-018-04675-x
Peng J, Santiago IJ, Ahn C, Gür B, Tsui CK, Su Z, Xu C, Karakhanyan A, Silies M, Pecot MY (2018)
Drosophila Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms. eLife 7: e33962. doi: 10.7554/eLife.33962.
Burgos A, Honjo K, Ohyama T, Qian CS, Shin GJ, Gohl DM, Silies M, Tracey WD, Zlatic M, Cardona A, Grueber WB (2018)
Nociceptive interneurons control modulator motor pathways to promote escape behavior in Drosophila
eLife 7: e26016, doi: 10.7554/eLife.26016.
Ramos-Traslosheros G, Henning M and Silies M (2018)
Motion detection: cells, circuits, algorithms
Neuroforum 24: doi: 10.1515/nf-2017-A028
2017
Neuert H, Yuva Aydemir Y, Silies M#and Klämbt C# (2017)
Different modes of APC/C activation control growth and neuron-glial interactions in the developing Drosophila eye
Development, 144: 4673-4683. #corresponding authors
2015
Fisher YE*, Leong JCS*, Sporar K, Ketkar MD, Gohl DM, Clandinin TR and Silies M (2015)
A Class of Visual Neurons with Wide-Field Properties Is Required For Local Motion Detection
Current Biology, 25: 3178-3189. *equal contribution
Fisher YE*, Silies M* and Clandinin TR (2015)
Orientation Selectivity Sharpens Motion Detection in Drosophila.
Neuron, 88: 390-402. * equal contribution
Sugie A, Hakeda-Suzuki S, Suzuki E, Silies M, Shimozono M, Möhl C, Suzuki T, Tavosanis G (2015)
Molecular Remodeling of the Presynaptic Active Zone of Drosophila Photoreceptors via Activity-Dependent Feedback
Neuron, 86: 711-725.
2014
Silies M and Clandinin TR (2014)
EM-erging Motion-Detecting Circuits
Current Biology, 24: R390-392.
Silies M, Gohl DM, and Clandinin TR (2014)
Motion-Detecting Circuits in Flies: Coming Into View
Annual Review of Neuroscience, 37: 307-327.
Gohl DM, Freifeld F, Silies M, Hwa JJ, Horowitz M and Clandinin TR (2014)
Large-scale mapping of transposable element insertion sites using digital encoding of sample identity
Genetics, 196: 615-623.
Clark DA, Fitzgerald JE, Ales JM, Silies M, Gohl DM, Norcia AM and Clandinin TR (2014)
Flies and humans use a shared computational strategy that exploits natural scene statistics to estimate motion
Nature Neuroscience, 17: 296-303.
2013
Silies M*, Gohl DM*, Fisher YE, Freifeld L, Clark DA and Clandinin TR (2013)
Modular use of peripheral input channels tunes motion-detecting circuitry
Neuron, 79: 111-127. *equal contribution
Gao XJ, Potter CJ, Gohl DM, Silies M, Katsov AY, Clandinin TR and Luo L (2013)
Specific kinematics and motor-related neurons for aversive chemotaxis in Drosophila
Current Biology, 23: 1163-1172.
2012
Burke C, Huetteroth W, Krashes M, Gohl DM, Silies M, Certel S, Perisse E, Das G, Owald D and Waddell S (2012)
Layered reward signaling through octopamine and dopamine in Drosophila
Nature, 492: 433-437.
Gohl DM, Silies M and Clandinin TR (2012)
Drosophila as a genetic model to investigate motion Vision
In: The Making and Un-Making of neuronal circuits in Drosophila. BA Hassan, ed. (Springer Science and Business Media, LLC).
Manzo A, Silies M, Gohl DM and Scott K (2012)
Motor neurons controlling fluid ingestion in Drosophila
Proc Natl Acad Sci USA, 109: 6309 – 6312.
2011
Gohl DM, Silies MA, Gao XJ, Bhalerao S, Luongo FJ, Lin CC, Potter CJ and Clandinin TR (2011)
A versatile in vivo system for directed dissection of gene expression patterns
Nature Methods 8: 231-237. doi: 10.1038/nmeth.1561
Silies M and Klämbt C (2011)
Adhesion and signaling between neurons and glial cells in Drosophila
Curr Opin Neurobiol 21: 11-16.
2010
Silies M and Klämbt C (2010)
APC/C-Fzr/Cdh1 dependent regulation of cell adhesion controls glial migration in the Drosophila PNS
Nature Neuroscience 13: 1357-1364.
Silies M, Yuva-Aydemir Y, Franzdottir SR and Klämbt C (2010)
The eye imaginal disc as a model to study the coordination of neuronal and glial development.
Fly (Austin) 4: 71-79.
2009
Stork T, Thomas S, Rodrigues F, Silies M, Naffin E, Wenderdel S and Klämbt C (2009)
Drosophila NeurexinIV stabilizes neuron-glia interactions at the CNS midline by binding to Wrapper
Development 136: 1251-1261.
2008
Stork T, Engelen D, Krudewig A, Silies M, Bainton RJ and Klämbt C (2008)
Organization and function of the blood-brain barrier in Drosophila
Journal of Neuroscience 28: 587-97.
2007
Silies M, Edenfeld G, Engelen D, Stork T and Klämbt C (2007)
Development of the peripheral glial cells in Drosophila
Neuron Glia Biol. 3: 35-43.
Silies M, Yuva Y, Engelen D, Aho A, Stork T and Klämbt C (2007)
Glial cell migration in the eye disc
Journal of Neuroscience 27: 13130-13139.